Ocena profilu lipidowego i leptynemii u zdrowych donoszonych noworodków

Abstract

IntroductionThe existence of a relation between the leptin concentration – a hormone taking part in the metabolism of the organism, and the lipids and lipoproteins seems undoubted, till now it has not yet been defined for newborns. AimThe aim of the study was to determine the value of the lipid profile parameters: ApoA, ApoB, TC, LDL-C, HDL-C, TG, albumines and leptin in healthy, full-term newborns, as well as to analyze the relation between leptin concentration and the values of the lipids parameters. Material and MethodsSerum Concentrations of TC, HDL-C, LDL-C, TG, ApoA, ApoB, albumines and leptin were assesed in the serum between 3–7 day of life 35 healthy, full term newborns with appropriate birth weight. ResultsIn female newborns significantly higher LDL-C concentration was found (p=0.03). The girls had a higher concentration of ApoA, ApoB, TC, HDL-C and leptin than boys (p=0,03). Positive correlation between the leptin serum concentrations and body weight (r=0.3681, p=0.03) and length of newborns (r=0.4714, p=0.004) was stated. Numerous correlations between the lipids parameters and a significant (p<0.5) decrease of ApoA (r = −0.4598), TC (r = −0.3635), HDL-C (r = −0.3473) and LDL-C (r = −0.3398) in serum concentrations accompanied by an increase in leptin concentrations were found. Conclusions1. The full-term healthy newborns have a significant correlation between leptin concentration and the values of ApoA, TC, HDL-C and LDL-C. 2. Newborns show a positive correlation between leptin concentration and body weight and length at birth. 3. The sex of full-term healthy newborn may be the factor modulatory the values of the lipid profile parameters.