Abstract

Synopsis The relationship between the histological grade and the steroid action mechanism was investigated in human endometrial cancer. The concentration and detection rate of cytosol estrogen (ER) and progestin receptor (PR) tended to decrease, and the rate of detected both ER and PR decreased as the tumor progressed from well differentiated to poorly differentiated grades. It appears that the mechanism of action of estrogen is impaired in undifferentiated cancer. The total quantity and detection rate in the nuclear binding of estrogen-ER complexes tended to increase and those of progestin-PR complexes tended to decrease as the tumor grade advanced. One may speculate that estrogen is biologically effective due to the increased nuclear binding sites of estrogen-ER complex instead of decreased cytosol receptor sites in undifferentiated tumors.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.