Abstract
Persistent polyclonal B cell lymphocytosis (PPBL) is a rare indolent condition characterized by a polyclonal expansion of B cells associated with binucleated lymphocytes observable on blood smears. Though polyclonal, recurrent genetic abnormalities have been described in PPBL, supernumerary isochromosome 3q (+i(3)(q10)) being the most frequently described. We report here two clinical observations showing the occurrence of NHL after the diagnosis of PPBL. These observations lead us to recommend a closer follow-up of PPBL patients and raise the question of a relationship between PPBL and NHL.
Highlights
Persistent polyclonal B cell lymphocytosis (PPBL) is a rare but rather indolent condition [1], affecting mainly middle-aged smoking women, and characterized by a polyclonal expansion of B cells associated with binucleated lymphocytes [2] and an increased polyclonal IgM serum level
We report the cases of two patients with PPBL, where B-NHL occurred after PPBL diagnosis, splenic zone marginal lymphoma (SMZL) and diffuse large B-cell lymphoma (DLBCL), leading us to raise the question of a relationshipbetween PPBL and B
Some features could suggest a link between PPBL and SMZL
Summary
Persistent polyclonal B cell lymphocytosis (PPBL) is a rare but rather indolent condition [1], affecting mainly middle-aged smoking women, and characterized by a polyclonal expansion of B cells associated with binucleated lymphocytes [2] and an increased polyclonal IgM serum level.
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