Abstract
An analysis has been made of the relationship between neuron specific enolase (NSE) in serum and immunohistochemically identified occurrence of NSE in the primary tumour in 56 patients with small cell lung cancer (SCLC). Patients were referred to the Finsen Institute for treatment during a period of 18 months. Forty-six tumours (82%) were NSE positive. To compare this staining with the occurrence of NSE in serum, a histological staining index (HSI) was established by semiquantitative gradation of the staining. No significant differences were found between distribution of serum NSE values in different HSI categories, and a high ranking in HSI was not associated with a high level of serum NSE. Both univariate and multivariate analysis selected serum NSE and not HSI as the most influential prognostic factor in SCLC.
Highlights
The present study was undertaken in order to describe the relation between serum neuron specific enolase (NSE) levels and the occurrence of staining in small cell lung cancer (SCLC) tumour tissue and to assess the possible prognostic value of the presence of NSE in SCLC tumour tissue
During a period of 18 months 101 patients with SCLC were referred to The Finsen Institute for treatment
No significant difference was found between distribution of HSE indices in LD and ED (Table II)
Summary
Ltd., Occurrence of neuron specific enolase in tumour tissue and serum in small cell lung cancer. Summary An analysis has been made of the relationship between neuron specific enolase (NSE) in serum and immunohistochemically identified occurrence of NSE in the primary tumour in 56 patients with small cell lung cancer (SCLC). The gamma-gamma dimer of the enzyme neuron specific enolase (NSE) has in small cell lung cancer (SCLC) been isolated in tissue cultures, tumour tissue and from patients serum (Carney et al, 1982; Gazdar et al, 1981, 1985; Marangos et al, 1982; Schmechel et al, 1978). The present study was undertaken in order to describe the relation between serum NSE levels and the occurrence of staining in SCLC tumour tissue and to assess the possible prognostic value of the presence of NSE in SCLC tumour tissue
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