Occurrence of Metabolic Syndrome in Untreated Bipolar Disorders: A Cross-Sectional Study.

Abstract

This cross-sectional study aimed to observe the occurrence of metabolic syndrome in untreated individuals with bipolar disorders. A total of 125 untreated individuals with bipolar disorders were collected as the study group, and 201 cases from the health examination center of our hospital were selected as the control group. The participants enrolled were assessed for general demographic data, case characteristics, and metabolic indexes including body mass index (BMI), blood pressure, triglyceride, HDL-C, cholesterol, LDL-C, and fasting plasma glucose. The incidence of metabolic syndrome in the bipolar disorders group was higher compared to the control group (9.6% VS. 8.5%). After calibrating sex and age data, a significant difference between the two groups was observed (P<0.05). Diastolic and systolic blood pressure were higher in the bipolar disorders group compared to the control group (P<0.01). Men with bipolar disorders had a higher risk of developing metabolic syndrome than women (14.5% vs. 5.8%). Bipolar disorders, sex, age, and BMI were identified as independent risk factors for metabolic syndrome. No significant difference was found in terms of metabolic index and incidence of metabolic syndrome between individuals with depressive episodes (n=37) and manic episodes (n=75). Patients with bipolar disorders were found to have a higher risk of developing metabolic syndrome than healthy individuals. Bipolar disorders, male sex, age, and BMI may contribute to an increased risk of developing metabolic syndrome.