Abstract
An oversulfated dermatan sulfate (DS) was isolated from bovine and human kidney glycosaminoglycans by elution at high NaCl concentrations through ion-exchange column chromatography. Based on its behavior on paper chromatography and electrophoresis after digestion with chondroitinases, the presence of an oversulfated DS was evidenced by detection of the umsaturated disulfated disaccharide unit. Judging from its susceptibility to chondrosulfatases, it was found that the oversulfated DS comprised mainly the disaccharide unit of iduronosyl-N-acetyl-<i>D</i>-galactosamine 4- and 6-sulfates. A possible function of the oversulfated DS in kidney tissue is discussed.
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