Abstract
ABSTRACTOne hundred and twenty‐one children showing symptoms of acute upper respiratory disease were bled during a period of nine months, from winter to summer, for detection of complement‐requiring neutralizing (CRN) antibody against herpes simplex virus. Six of the cases, all from children under the age of 13 years, were unequivocally related to herpetic infection as evidenced by the presence of anti‐herpes CRN antibody. During the same period, 144 other children who were normal healthy or suffering from unrelated non‐febrile diseases were tested as controls; anti‐herpes CRN antibody was not detected in any of them. Further, the age distribution of individuals with antibodies was compared between patients in the acute upper respiratory disease group and the control group. This analysis showed that approximately 5 to 7% of the acute upper respiratory diseases in the young children in this study would be attributed to herpetic infection.
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