Occurrence, fate, and ecotoxicity of antibiotics in agro-ecosystems. A review

Abstract

Globally, besides human medicine, an increasing amount of antibiotics as veterinary drugs and feed additives are used annually in many countries with the rapid development of the breeding industry (livestock breeding and aquaculture). As a result, mostly ingested antibiotic doses (30–90%) and their metabolites to humans and animals, as emerging persistent contaminants, were excreted together with urine and feces, and subsequently disseminated into environmental compartments in forms of urban wastewater, biosolids, and manures. More importantly, significant amount of antibiotics and their bioactive metabolites or degradation products were introduced in agro-ecosystems through fertilization and irrigation with antibiotics-polluted manures, biosolids, sewage sludge, sediments, and water. Subsequently, accumulation and transport of antibiotics in soil–crop systems, particularly soil–vegetable systems, e.g., protected vegetable and organic vegetable production systems, poses great risks on crops, soil ecosystem, and quality of groundwater- and plant-based products. The aim of this review is to explore the sources, fates (degradation, adsorption, runoff, leaching, and crop uptake), and ecological risks of antibiotics in agro-ecosystems and possible food security and public health impacts. Three topics were discussed: (1) the occurrence, fates, and ecological impacts of antibiotics in agro-ecosystems, a global agro-ecological issue; (2) the potential ecological risks and public health threat of antibiotic pollution in soil–vegetable system, especially protected vegetable and organic vegetable production systems; and (3) the strategies of reducing the introduction, accumulation, and ecological risks of antibiotics in agro-ecosystems. To summarize, environmental contamination of antibiotics has become increasingly serious worldwide, which poses great risks in agro-ecosystems. Notably, protected vegetable and organic vegetable production systems, as public health closely related agro-ecosystems, are susceptible to antibiotic contamination. Occurrence, fate, and ecotoxicity of antibiotics in agro-ecosystems, therefore, have become most urgent issues among antibiotic environmental problems. Nowadays, source control, including reducing use and lowering environmental release through pretreatments of urban wastes and manures is a feasible way to alleviate negative impacts of antibiotics in agro-ecosystems.