Occurrence and enantiomer profiles of β-blockers in wastewater and a receiving water body and adjacent soil in Tianjin, China

Abstract

A total of 58 samples were collected from hospitals, municipal wastewater treatment plants (WWTPs), a receiving water body (Dagu Drainage Canal, DDC), and adjacent farmland in Tianjin City, China, in May and November 2013 and were analyzed for five common β-blockers (atenolol, sotalol, metoprolol, propranolol, and nadolol) to elucidate their source, occurrence and fate in a typical city in China. The profiles of the enantiomers of the β-blockers in some samples were examined. Sotalol, metoprolol and propranolol were frequently detected, atenolol was less frequently detected, and nadolol was mostly not detected. Generally, the concentrations in hospital wastewaters occurred from <LOQ to 10 μg/L, while concentrations in municipal WWTP water samples ranged from <LOQ to 5.2 μg/L. Hence, both hospitals and WWTPs acted as sources of β-blockers in the environment. Sotalol, metoprolol and propranolol were determined in soils adjacent to the DDC with concentrations up to hundreds of ng/kg in the topsoil and declining levels in the subsoil. Seasonal variation was observed with samples obtained in May showing higher concentrations, both in the canal and the adjacent soil, which could be ascribed to greater consumption of these drugs, lower temperature and less precipitation in the spring and the former winter. Enantiomeric fractions (EFs) of metoprolol and propranolol in soil samples showed a trend of enrichment of E1 (first-eluted) compared to E2 (second-eluted), while sotalol was almost racemic. In the DDC, no significant difference was found for the pair enantiomers of each β-blocker, while in hospital and WWTP wastewaters, E1 predominated.