OCCURENCE OF ADVERSE PREGNANCY OUTCOMES AND ITS RELATION TO LIPID PROFILE IN EARLY PREGNANCY IN WOMEN ATTENDING IN TERTIARY CARE CENTRE

Abstract

Background: Maternal dyslipidemia has been linked to adverse perinatal outcomes. Hypercholesterolemia and elevated triglycerides in early pregnancy have been associated with an increased risk for gestational hypertension and adverse perinatal outcomes. The present study aimed to know the occurrence of adverse pregnancy outcomes among dyslipidemic pregnant females in rst trimester and the relationship between maternal lipid prole in early pregnancy and birth outcomes. Material and methods: Serum lipid levels of total 124 pregnant females were taken in rst trimester in a large tertiary care teaching hospital in New Delhi and they were followed up for their pregnancy and perinatal outcomes. The outcomes were stratied by normal and elevated lipid levels. Results: 41.9% pregnant females were found to be dyslipidemic. The common morbidities were gestational Hypertension (10.5)% and gestational diabetes (16.1%). The overweight females (BMI, 25-30 kg/m2) in hyperlipidemia group (61.5%) were more than normal lipid group (36.1%). (p<0.01). Babies with birth weight between 3.5- 4 kg were all born to mothers having hyperlipidemia during rst trimester (N=8). (p <0.01). Babies with birth weight falling under large for gestation (LGA) category were signicantly more in hyperlipidemia group (15.4%) compared to normal lipid group (2.8 %) (p<0.05). Mean serum total cholesterol and triglyceride was signicantly higher in women >30 years compared to women less than 30 years. Conclusion: Risk of gestational hypertension, preeclampsia and gestational diabetes was higher in females with hyperlipidemia in rst trimester. Hyperlipidemia and gestational diabetes were responsible for large for gestation birth weights