Abstract
The authors report the case of a veterinarian who acquired brucellosis infection by accidental exposure to Brucella abortus vaccine (BRUCEL-VET B19) while performing animal vaccination. Antibiotic prophylaxis with doxycycline and rifampin for six weeks was indicated, but rifampin was discontinued after 10 days due to gastrointestinal intolerance. Despite prophylaxis, the patient seroconverted after 30 days, but was asymptomatic and did not require additional antibiotic therapy. Post-exposure prophylaxis of Brucella is not free from side effects and asymptomatic seroconversion can occur despite prophylaxis.
Highlights
Brucellosis is a bacterial zoonosis responsible for more than half a million new human cases annually, mainly in developing countries[1]
Brucella abortus vaccine is part of the mandatory sanitary measures recommended by the National Program for Control and Eradication of Brucellosis and Animal Tuberculosis in Brazil, and the reported patient was exposed while routinely vaccinating cattle
Accidents during the administration of live attenuated brucellosis vaccines with dermal inoculation are of high risk for human infection and post-exposure prophylaxis is indicated[9,10,11]
Summary
Occupational infection to Brucella abortus B19 vaccine despite antimicrobial prophylaxis. Alexandre Sampaio Moura[1 ], Letícia Mattos Menezes[2 ], Marcelle Amaral de Matos[3 ], Cynthya Magalhães Costa[3 ], Bruna Arantes Borges[3]
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