Abstract

Objectives:This study aimed to estimate the risk of lymphoma and its major subtypes in relation to occupational exposure to specific organic dusts.Methods:We explored the association in 1853 cases and 1997 controls who participated in the EpiLymph case–control study, conducted in six European countries in 1998–2004. Based on expert assessment of lifetime occupational exposures, we calculated the risk of the major lymphoma subtypes associated with exposure to six specific organic dusts, namely, flour, hardwood, softwood, natural textile, synthetic textile, and leather, and two generic (any types) groups: wood and textile dusts. Risk was predicted with unconditional regression modeling, adjusted by age, gender, study center, and education.Results:We observed a 2.1-fold increase in risk of follicular lymphoma associated with ever exposure to leather dust [95% confidence interval (CI) 1.01–4.20]. After excluding subjects who ever worked in a farm or had ever been exposed to solvents, risk of B-cell lymphoma was elevated in relation to ever exposure to leather dust [odd ratio (OR) 2.2, 95% CI 1.00–4.78], but it was not supported by increasing trends with the exposure metrics. Risk of Hodgkin lymphoma was elevated (OR 2.0, 95% CI 0.95–4.30) for exposure to textile dust, with consistent upward trends by cumulative exposure and three independent exposure metrics combined (P=0.023, and P=0.0068, respectively).Conclusions:Future, larger studies might provide further insights into the nature of the association we observed between exposure to textile dust and risk of Hodgkin lymphoma.

Highlights

  • ObjectivesThis study aimed to estimate the risk of lymphoma and its major subtypes in relation to occupational exposure to specific organic dusts

  • We investigated the association between exposure to specific organic dusts, selected at the early stage of planning the study based on an extensive literature search on occupational risk factors, namely wood dust, hardwood, softwood, textile dust, natural textile, synthetic textile, flour dust, and leather dust, and risk of lymphoma overall, B-cell lymphoma, and five major lymphoma subtypes

  • Our results provide tentative evidence of an increased risk of some lymphoma subtypes associated with exposure to specific organic dusts

Read more

Summary

Objectives

This study aimed to estimate the risk of lymphoma and its major subtypes in relation to occupational exposure to specific organic dusts

Methods
Results
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call