Abstract
BackgroundChronic rhinosinusitis (CRS) is defined as a condition of inflammation in the paranasal sinus mucosa persisting for more than 12 weeks. We previously reported that the prevalence of CRS was about 8 % in China. Here, we aim to investigate the occupational and environmental risk factors associated with CRS.MethodsData were collected from seven Chinese cities: Urumqi, Changchun, Beijing, Wuhan, Chengdu, Huaian and Guangzhou. CRS was diagnosed according to the European Position Paper on Rhinosinusitis and Nasal Polyps (EP3OS) document. Participants were asked to complete a standardized questionnaire, which was developed by the Global Allergy and Asthma European Network (GA2LEN) project and covered sociodemographic characteristics, CRS-related symptoms and occupational and environmental exposures. We evaluated the association between CRS and various occupational and environmental factors using odds ratios (ORs) and 95 % confidence intervals (95 % CIs).ResultsThe total study population consisted of 10,633 subjects, 850 (7.99 %) of whom were defined as having CRS according to the EP3OS criteria. We found that there were significant associations between occupational and environmental factors and CRS. Specifically, having a clearance-related job, occupational exposure to dust, occupational exposure to poisonous gas, a pet at home or carpet at home or at the workplace were risk factors for CRS. Additionally, the method used to keep warm in winter, the duration of time spent using air conditioning in summer and the frequency of exposure to mouldy or damp environments were significantly different in subjects with and without CRS.ConclusionsOur data showed that some occupational and environmental exposures are strongly associated with CRS, which aids in understanding the epidemiology of CRS.
Highlights
Chronic rhinosinusitis (CRS) is defined as a condition of inflammation in the paranasal sinus mucosa persisting for more than 12 weeks
The present study further investigated the detailed occupational and environmental risk factors associated with CRS based on the dataset of this sevencity survey
Comparisons of sociodemographic characteristics between the two groups The total study population consisted of 10,633 subjects, 851 (7.99 %) of whom were defined as having CRS according to the EP3OS criteria, and the response rate of the total study population was 87 % [2]
Summary
Chronic rhinosinusitis (CRS) is defined as a condition of inflammation in the paranasal sinus mucosa persisting for more than 12 weeks. We previously reported that the prevalence of CRS was about 8 % in China. We aim to investigate the occupational and environmental risk factors associated with CRS. Chronic rhinosinusitis (CRS), one of the most common chronic diseases, is defined as a condition of inflammation in the paranasal sinus mucosa persisting for more than 12 weeks. CRS was more prevalent in people with specific medical conditions, including allergic rhinitis, asthma, chronic obstructive pulmonary disease and gout. The present study further investigated the detailed occupational and environmental risk factors associated with CRS based on the dataset of this sevencity survey. The identification of risk factors is important for providing further guidance to prevent CRS
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