Abstract
IntroductionThe ovary is a common site of metastasis from various organs. However, little is known about gallbladder carcinoma metastasizing to the ovaries and presenting as a primary ovarian tumor.Case presentationWe report two cases of a metastatic gallbladder carcinoma which mimicked a primary ovarian tumor in a 35-year-old and a 62-year-old North Indian woman. Clinically, both our patients presented with abdominal masses without obvious signs and symptoms related to gallbladder carcinoma. Radiology suggested the possibility of a primary ovarian tumor with chronic cholecystitis and cholelithiasis. The gross features also mimicked a primary malignant ovarian tumor in the first case and a benign mucinous neoplasm in the second case. Exact diagnoses could only be made after thorough sampling from both the ovaries and gallbladder.ConclusionsGallbladder carcinoma with metastasis to the ovaries can mimic both malignant and benign primary ovarian tumors. Extensive cystic change in the ovary due to metastasis from gallbladder carcinoma has rarely been reported. A high index of suspicion and thorough sampling are essential to avoid misdiagnosis in such cases.
Highlights
The ovary is a common site of metastasis from various organs
Metastasis from gallbladder to ovaries, though known, is rare with only few reports available in the English literature [2,3,4,5,6,7,8,9]. Some of these were initially misdiagnosed as a primary ovarian tumor
A figure of 6% cases of gallbladder carcinoma with metastasis to ovary has been quoted by Albores-Saavedra [10], a description of only 19 such cases could be found in the literature (Table 1) [2,3,4,5,6,7,8,9]
Summary
Gallbladder carcinoma should be added to the previously known list of origins of metastatic tumors to the ovary that can closely mimic primary ovarian mucinous tumors. Knowledge of the extent to which gallbladder metastasis may mimic a primary ovarian tumor and its differentiating histological features may help in correct diagnosis and further management of the patient. Author details 1The Pine, Near Ashiana Regency, Chhota Shimla, Shimla -171002, India. AC and AB helped in drafting of manuscript and given their valuable suggestions, MG provided the images. All the authors read and approved the final manuscript. Competing interests The authors declare that they have no competing interests
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