Abstract
Occlusion pressure (P100) at rising inspiratory CO2 concentration was measured in 9 healthy adults and in two groups of patients with chronic obstructive lung disease, of which 29 had an arterial CO2 tension (PaCO2) of less than 43 mm Hg and 15 a PaCO2 of more than 43 mm Hg. Statistically the three groups could be separated significantly from each other in terms of occlusion pressure at rising alveolar CO2 tensions (PACO2). At a standard endexpiratory PACO2 of 60 mm Hg the absolute values of P100 of the obstructive patients with a normal PaCO2 are significantly higher than those of the two other groups. The differences in ventilatory response between the three groups are discussed.
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