Abstract
Occlusal hypofunction mediates alveolar bone apposition via relative augmentation of TGF-βsignaling by decreased Asporin production in rats
Highlights
The periodontal ligament (PDL) is a fibrous connective tissue that is interposed between the roots of the teeth and the alveolar bone
We discovered that occlusal hypofunction increased the alveolar bone apposition and downregulated Asporin expression in PDL fibroblasts
We firstly reported that occlusal hypofunction mediates alveolar bone apposition via relative augmentation of TGF-β signaling by decrease of Asporin production
Summary
The periodontal ligament (PDL) is a fibrous connective tissue that is interposed between the roots of the teeth and the alveolar bone. The effects of occlusal hypofunction on the periodontal tissue have been studied [2,3,4,5,6,7,8] These studies indicated that occlusal hypofunction results in atrophic changes of the PDL, narrowing of periodontal width [5,6,7], and increased alveolar bone formation [2,3,8]. Occlusal hypofunction narrows the PDL by alveolar bone apposition [2,3]. At this point, the molecules involved in the alveolar bone apposition by occlusal hypofunction are unknown
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