OC69 Peculiarities of neuron-specific enolase changes in children with helicobacter pylori-associated chronic gastroduodenitis

Abstract

The aim of the study was to assess changes in the level of neuronspecific enolase (NSE) in children with chronic gastroduodenitis (CGD), taking into account the presence of Helicobacter pylori (HP) and the severity of the disease. Materials and methods 73 children aged 8–15 years with CGD were examined. The first group included 30 children with CGD associated with the HP (HP+). In the II group – 43 children with CGD are not associated with HP (HP–). Groups I and II included children with superficial gastroduodenitis (SGD) and erosive gastroduodenitis (EGD). The control group (CG) consisted of 28 children I–II health groups. The level of NSE in blood serum was determined by the method of enzyme immunoassay. Results The level of NSE in group I and II children exceeded the values of NSE in CG: 10.87 (9.9–12.3) μg/l; 11.24 (9.95–12.23) μg/l and 9.79 (8.49–10.90) μg/l, p≤0.01. In group I the largest value of NSE revealed by EGD HP+: 12.14 (11.24–12.27) μg/l in comparison with the level of NSE in children with SGD HP+: 10.07 (9.95–11.42) μg/l, p≤0.01. In group II, the value of NSE at the SGD HP–: 11.10 (10.50–12.34) μg/l exceeded the level of the NSE of children with EGD HP–: 10.49 (9.47–10.61) μg/l, p≤0.01. The level of NSE in patients with EGD HP+ higher values of the index EGD in HP–: 12.14 (11.24–12.27) μg/l and 10.49 (9.47–10.61) μg/l, p≤0.01. The high indices of NSE in children with SGD HP– compared to SGD HP+: 11.10 (10.5–12.34) μg/l and 10.07 (9.95–11.42) μg/l, p≤0.05. Conclusion An increase in the level of NSE in serum in children with HCG outside Association with HP-infection was revealed. The opposite direction of changes in the NSE depending on the severity of the disease indicates the participation of the studied factor in the pathogenesis of CGD.