OC211: Doppler sonography of uterine arteries at 20–23 weeks: depth of notch predicts probability of adverse pregnancy outcome and degree of IUGR

Abstract

although the NDI was defined as zero in the absence of a notch. The averaged values of resistance index (RI) and NDI from the right and left uterine artery were used for statistical analysis. We measured the serum levels of PlGF and sFlt-1 during both 16–23 and 27–29 weeks of gestation. The cut-off values for RI, NDI, sFlt-1 and sFlt-1/PlGF ratio were set at the 90th percentile, and the cut-off value for PlGF at the 10th percentile. Results: Pre-eclampsia occurred in 5.0%. The area under the curve (AUC) of NDI for pre-eclampsia was larger than that of RI (0.777 vs. 0.687), and the AUC of PlGF was larger than that of sFlt-1 in the second trimester (0.672 vs. 0.561). Therefore, we selected the NDI and PlGF as the appropriate risk factors for the occurrence of pre-eclampsia. In women with both normal (Group 1, n = 221), only abnormal PlGF (Group 2, n = 14), only abnormal NDI (Group 3, n = 16), and both abnormal (Group 4, n = 9), the frequencies of high sFlt-1/PlGF ratio in the early third trimester were 6.8%, 21.4%, 0%, and 100%, respectively (P < 0.001), and the frequencies of pre-eclampsia were 2.7%, 0%, 6.3% and 66.7%, respectively (P < 0.001). Conclusions: A high sFlt-1/PlGF ratio in the early third trimester and pre-eclampsia may frequently occur in women with both a high NDI and low PlGF levels in the second trimester.