OC14.01: Using a model based on serum biochemistry at 4 and 5 weeks gestation to predict immediate viability and viability at 12 weeks in IVF pregnancies

Abstract

Objectives: Many fetuses with vascular ring have been screened recently. The range of symptoms after birth are very wide, from no symptom to severe dyspnea. The objective of this study was to evaluate the fetal tracheal stenosis of vascular ring by new methods. Methods: 20 fetuses with vascular ring, 3 with double aortic arch and 17 with right aortic arch and, as a control group, 100 cases without cardiovascular anomalies were included. 3DCT were performed after birth to evaluate the tracheal stenosis. 2 cases with severe tracheal stenosis by 3DCT and severe dyspnea were operated, division of the ring and tracheal repair. 5 cases with mild tracheal stenosis by 3DCT and no dyspnea were followed several months and operated, division of the ring, because of mild dyspnea. The other 13 cases have no tracheal stenosis by 3DCT and no symptom. We evaluated retrospectively the tracheal stenosis by these two methods. Method 1 to evaluate the tracheal size on the ring level. Group 1 with stenosis, Group 2 no stenosis. Method 2 to calculate the area inside the ring, AIR. Group 1 with narrow ring, AIR less than 0.6 cm2, Group 2 with wide ring, AIR more than 0.6 cm2. Results: In Method 1, 2 cases with sever tracheal stenosis belonged in Group 1. The other cases with mild and no tracheal stenosis and control group belonged in Group 2. In Method 2, 2 cases with severe tracheal stenosis and 1 case with mild stenosis and 1 case with no stenosis belonged in Group 1. The other cases with mild and no tracheal stenosis and control group belonged in Group 2. Conclusions: Method 1 and 2 are new evaluating methods of tracheal stenosis, which will make the accurate fetal evaluation of tracheal stenosis and poor outcome possible. In this study, the statistical analysis is not possible because of small number of cases, but multicenter study will be done in future.