OC-070 A NOVEL SELF-GRIPPING LONG-TERM RESORBABLE MESH PROVIDING TEMPORARY SUPPORT FOR PRIMARY VENTRAL AND INCISIONAL HERNIA

Abstract

Abstract Medtronic recently developed a novel synthetic fully long-term resorbable self-gripping mesh to reinforce soft tissue where weakness exists during ventral hernia repair procedures. This resorbable mesh is a macroporous, knitted, poly-L-lactide, poly-trimethylene carbonate copolymer monofilament mesh with the ProGrip™ technology. The biocompatibility profile of the mesh has been extensively established and documented. No systemic nor local adverse reactions have been observed from implantation to complete resorption and metabolization of the mesh in a subcutaneous implantation preclinical rabbit model. Its performance was evaluated at 20 weeks using a modified published preclinical porcine model of hernia repair (Martin, 2013; Deeken, 2013). Histologic examination of the implantation sites confirmed that this novel mesh was well tolerated and led to new extracellular collagen matrix formation. The burst strength of the hernia repair sites reinforced with the new mesh was statistically equivalent to the one of the native abdominal walls. Currently marketed ProGrip™ meshes have been clinically and successfully used with less mechanical fixation devices than non-self-gripping meshes (Chastan, 2009; Rangwani, 2021). The new self-gripping long-term resorbable mesh fixation performance was demonstrated to be statistically equivalent to the one of ProGrip™ Self-Gripping Polyester Mesh both in ex-vivo testing and in an in vivo porcine model. This should support the ease-of-use feature of the mesh with a limited need for additional mechanical fixation, which will likely be associated with a shorter surgical time. The preclinical tests of the self-gripping resorbable mesh are compelling enough to make it a new mesh candidate for future clinical use.