Abstract
Background It is known that syndecan 1 in inflammatory bowel diseases is able to migrate from epithelial basolateral site to the stromal area and apical surface of epithelium with a consequent activation and modulation of basic fibroblast growth factor (bFGF), and this process sustains mucosal healing of ulcers. On the other hand, tumour necrosis factor (TNF) a mucosal levels are directly related to the entity of the damage in these disorders. Aim of the study A ‘post-hoc’ retrospective study was performed to estimate mucosal TNF a in rectal biopsies of subjects with ulcerative colitis (UC) before and after effective infliximab therapy and its relationship with syndecan 1, bFGF and endoscopic mucosal healing. Material and methods Paraffin-embedded rectal samples from 12 patients with UC responders to infliximab were analysed for TNF a, syndecan 1 and bFGF before and 6 months after therapy using a real-time reverse transcriptase polymersase chain reaction. Additionally, syndecan 1 location was evaluated by immunohistochemistry. Samples from 12 subjects with irritable bowel symptoms without endoscopic/ histological abnormalities represented the control group. Mucosal healing induced by the treatment was defined by an endoscopic Mayo subscore changing from 2e 3t o 0. ANOVA plus StudenteNewmaneKeuls was used for statistical analysis. Results The authors found that in the active disease, an increase in TNF a (p<0.001) is accompanied by raised levels of either syndecan 1 (p<0.005) and bFGF (p<0.005) compared with the control group 1
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