Abstract
Fig 1 shows a screenshot of Smart-Plan of the module where CT images of animal specimens are inspected for their electron density, and where a range of tissues is assigned to the very small voxels. The bottom panel shows a Monte Carlo dose distribution in a mouse thorax from 3 stationary photon beams in the range of 1-5 mm field size. The results are presented as dose-to-medium, meaning the photon transport was done in the proper media and doses are expressed in the media as well (an alternative is to express doses in water). The calculation times for a typical treatment plan are about 5 minutes. The dose verification in the heterogeneous phantom revealed good agreement between measured and calculated dose distributions. Conclusions: A novel radiotherapy treatment planning system for small animals was developed and validated. The system may play an important role in pre-clinical translational studies.
Published Version
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