Abstract
Results: The number of responders was 145 (45%) and 28 (49%), for the training and validation cohort, respectively. Feature space reduction resulted in a set of 34 highly robust and non-redundant features and subsequent model development lead to a multivariable model consisting of 8 features (Table 1) with an out-of-sample AUC of 0.63±0.09. Independent validation resulted in an AUC of 0.77. Model derived ROC curves for both the training and validation cohort and overall AUC values are shown in Figure 1b.
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