Abstract
Collagen is an important biomaterial in medical applications due to its special characteristics such as biodegradability and weak antigenicity. Thus collagen, as a new type of biomaterial, has been used in drug delivery systems and tissue engineering. In addition, collagen is closely linked to several diseases, such as rheumatoid arthritis and systemic sclerosis. Gelatine can be made into roll film and drug capsules and can also be used as a delivery system which is very different from the traditional capsule. Collagen hydrolysate is a polypeptide composite obtained through further hydrolysis of denatured collagen. It has been widely used in cosmetics as well as a food additive. The three major methods of collagen extraction produce neutral salt-solubilised collagen, acid-solubilised and pepsin-solubilised collagen.
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