Abstract
A simple dip coating procedure was used to prepare the magnesium doped hydroxyapatite coatings. An adapted co-precipitation method was used in order to obtain a Ca25−xMgx(PO4)6(OH)2, 25MgHAp (xMg = 0.25) suspension for preparing the coatings. The stabilities of 25MgHAp suspensions were evaluated using ultrasound measurements, zeta potential (ZP), and dynamic light scattering (DLS). Using transmission electron microscopy (TEM) and scanning electron microscopy (SEM) information at nanometric resolution regarding the shape and distribution of the 25MgHAp particles in suspension was obtained. The surfaces of obtained layers were evaluated using SEM and atomic force microscopy (AFM) analysis. The antimicrobial evaluation of 25MgHAp suspensions and coatings on various bacterial strains and fungus were realized. The present study presents important results regarding the physico-chemical and antimicrobial studies of the magnesium doped hydroxyapatite suspensions, as well as the coatings. The studies have shown that magnesium doped hydroxyapatite suspensions prepared with xMg = 0.25 presented a good stability and relevant antimicrobial properties. The coatings made using 25MgHAp suspension were homogeneous and showed remarkable antimicrobial properties. Also, it was observed that the layer realized has antimicrobial properties very close to those of the suspension. Both samples of the 25MgHAp suspensions and coatings have very good biocompatible properties.
Highlights
During recent years, constant efforts have been made in developing bioceramic materials and enhancing their mechanical and biological properties for use in biomedical applications [1,2,3,4,5]
In the current context, when looking for solutions to improve the quality of life, one of our concerns is the study of the stability of suspensions based on hydroxyapatite doped with different ions that could be used in different applications both in the medical field and in medical food such as would be the development of biocompatible coatings
For a better accuracy of the information regarding the stability of the suspension used in the making of coatings, ultrasonic measurements were made on the concentrated suspension obtained after the preparation process
Summary
Constant efforts have been made in developing bioceramic materials and enhancing their mechanical and biological properties for use in biomedical applications [1,2,3,4,5]. Due to their properties, bioceramic materials are usually used for developing bone substitutes both in medical and dental applications. The ongoing studies are focused on developing bone substitutes by tailoring materials having the physico-chemical and structural properties of the natural bone [11] The development of these types of materials with improved biocompatible and osteoconductive properties will help the process of the bone tissue natural healing [12]. The first successful medical use of calcium phosphates was reported by
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