Abstract
VATER association was first described in 1968 by Say and Gerald and is an association of congenital anomalies including V (vertebral defect), A (anal atresia), TE (tracheoesophegeal fistula), and R (radial dysplasia and renal defects). This report described a 26 year-old man with VATER association presented with infertility. Hormone tests including follicular stimulating hormone, luteinizing hormone and testosterone were normal. Semen analysis showed azoospermia. A testicular biopsy was performed and showed the presence of all of germinative components, germ cell sloughing, and mild hypospermatogenesis. The findings were compatible with obstructive azoospermia. No evidence of intratubular germ cell neoplasia unclassified was identified.
Highlights
Infertility can be attributed to men in 30% - 40% of infertile couples, which may be due to endocrine disruption of gonadal development during early pregnancy, environment pollution and genetic factors
Testicular biopsy plays a definitive role in confirming the obstructive azoospermia, which in turn leads to appropriate management
No obstructive azoospermia has been reported in the patients with VATER association
Summary
Infertility can be attributed to men in 30% - 40% of infertile couples, which may be due to endocrine disruption of gonadal development during early pregnancy, environment pollution and genetic factors. VATER association was first described in 1968 by Say and Gerald [1] and is an association of congenital anomalies including V ( vertebral defect), A (anal atresia), TE (tracheoesophegeal fistula), and R (radial dysplasia and renal defects) [2,3]. Since the introduction of the acronym, various expansions in an effort to further define the scope of the VATER association have been suggested, such as V in VATER was expanded to include vascular anomalies [4]. About half of the patients with VATER association show the urologic anomalies [6,7]. No obstructive azoospermia has been reported in the patients with VATER association. In this report a men with VATER association with an obstructive azoospermia was described
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