Abstract
ObjectiveTo evaluate whether carriers of group B streptococcus (GBS) have adverse obstetric and neonatal outcomes when preterm premature rupture of membranes (PPROM) occurs. MethodsIn a retrospective study, data were reviewed for women with a singleton pregnancy and PPROM before 34weeks who attended the Meir Medical Center, Kfar Saba, Israel, between 2005 and 2012. All women received roxithromycin for 1week, and ampicillin until GBS culture results were available. Ampicillin was continued to 1week if the GBS culture was positive. The primary study outcome measure was the latency period (time from rupture of membranes to active/induced labor). ResultsAmong 116 eligible patients, 21 (18.1%) were GBS carriers and 95 (81.9%) noncarriers. The latency period was 11.2±18.1days for GBS carriers versus 7.5±9.6days for noncarriers (P=0.93). However, there was a correlation between the length of ampicillin treatment and the latency period (Spearman correlation coefficient 0.7; P<0.001). There were no differences in early neonatal outcomes. ConclusionGBS carriers with PPROM did not have adverse outcomes. Longer treatment with ampicillin among GBS carriers prolonged the latency period.
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