Obstacles and side-effects of CAR-T from experiment to clinical

Abstract

There is a practical and promising therapy that comes out these days called CAR-T therapy. The human immune system detects certain alien cells by matching distinct antigens on their surface. T-cells trigger the immune system to attack the cancer cells by attaching the antigens with its receptors. CAR-T therapy just uses T-cell's ability to carry out the following treatment process. This therapy has already been applied to the treatment of leukemia. However, CAR-T cell treatments for solid tumors have not been well investigated. Because the lacking of samples and clinical trials causes some drawbacks and obstacles to Car-t therapy which can not be ignored. Some strong side effects include cytokine release syndrome (CRS) and neurological toxicity problems and some limitations in particular groups of people. Here, this article mainly focuses on the drawbacks and also talks about obstacles of CAR-T therapy from experiment to clinical which people have not solved yet. This review attempts to highlight some of the remaining issues in CAR T treatment and provide current clinical solutions for certain possible roadblocks.