Observed Colposcopy Practice in US Community-Based Clinics: The Retrospective Control Arm of the IMPROVE-COLPO Study.

Abstract

Objective:The aim of the study was to characterize colposcopy practice and management of women with cervical abnormalities in US community-based clinics.Materials and Methods:IMPROVE-COLPO was a 2-arm study of colposcopy patients with an abnormal screening result. The prospective arm recruited women to undergo examination with a commercial digital colposcope. The retrospective-control arm collected data (chart review) from previous colposcopies performed using standard equipment and methods. From the retrospective arm, we analyzed referral trends, colposcopy and biopsy practice, and management patterns.Results:We collected data of 3,602 eligible women (median age = 34 years) that had been examined from 2012 to 2017 by 154 colposcopists at 44 clinics across 12 states. Most patients were premenopausal (87.9%), privately insured (88.2%), and had a low-grade (low-grade squamous intraepithelial lesion/atypical squamous cells of undetermined significance/human papillomavirus positive) indication (87.2%). Most colposcopists performed less than 3 colposcopies monthly and their biopsy rate was1.47 biopsies/patient for high-grade referrals and 0.97 for low-grade referrals (p < .001). Random biopsy was rare (0.4% of biopsies). Most women(74.9%) underwent endocervical sampling, including 62.5% of women aged 21 to 24 years. Colposcopic impression was frequently not reported(58.8%), and its sensitivity to predict histology-confirmed cervical intraepithelial neoplasia (CIN) 2+ as “high-grade” was 56.5% for high-grade referrals and 23.2% for low-grade referrals. Excisions often (44.5%) returned <CIN 2, including patients aged 21–40 years (37.4%).Conclusions:In this analysis, most colposcopists performed few colposcopies and took less than 2 biopsies per patient. Colposcopic impression had a poor sensitivity to predict histology-confirmed CIN 2+. Although recent research indicates that taking multiple biopsies improves sensitivity and detection of CIN 2+, this is not being practiced in the US.