Abstract
Objective To investigate the therapeutic effect of combination of memantine and donepezil on cognitive mental symptoms in patients with Alzheimer's disease. Methods Seventy cases elderly patients with Alzheimer's disease were randomly divided into two groups, memantine and donepezil group(treatment group) with 35 cases, donepezil hydrochloride and olanzapine group(control group) with 35 cases.Scoring in before treatment and 6, 12 weeks after treatment in application of rosa linked to Alzheimer's disease(ROSA) and the neuropsychiatric Inventory(NPI) assessment, montreal cognitive assessment scale(MoCA scale) were assessed. Results ROSA scores in before treatment and 6, 12 weeks after treatment of treatment group and control group was (75.14±17.20) points and (73.97±17.29) points, (89.77±17.14) points and (80.84±15.31) points, (100.30±14.47) points and (89.31±13.30) points, there were statistically significant differences before treatment between the two groups(P 0.05). Conclusion The combined treatment of memantine and donepezil in Alzheimer's disease can improve cognitive function and mental symptoms, communication, etc.The effect of agitation or attack than the control group is significantly different. Key words: Alzheimer’s disease; Memantine; Aricept; Relevant Outcome Scale for Alzheimer's Disease
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