Abstract
It has been said by some astute critic that “insanity has no pathology,” but it would be a nearer approach to scientific truth if he had said that, with our present imperfect means of investigation, there are many cases of insanity in which no pathological changes can be discovered as the cause of the mental phenomena. The microscope, for example, has as yet failed to differentiate the delicate alterations in the protoplasm of the cerebral cells which result in an outburst of maniacal excitement; nevertheless, the ophthalmoscope shows changes in the vascular supply of the brain in many such cases, and, with the aid of the sphygmograph, light has been thrown on many hitherto obscure conditions of the circulation.
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