Abstract
In 1913, Rowntree, Hurwitz and Bloomfield, 1 in making a resume of all known methods for testing the functional capacity of the liver concluded that they were all of little value in that they did not deal with functions specific to the liver. They made the possible exception of the urobilonogen test, which they found positive in most mild diseases of the liver, but it gave no information as to the extent of liver injury, as it entirely lacked the quantitative side. It was of no value, therefore, from the standpoint of prognosis. During the course of a pharmacologic search for a cathartic of protracted action, it was discovered by Rowntree and Abel 2 in 1909, that phenoltetrachlorphthalein was eliminated entirely by the liver, and they described its properties. They found it to be an odorless, tasteless chrystalline substance, insoluble in water and forming deeply colored hydrolizable salts with alkalies. They found
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