Abstract
Summary In tuberculin positive subjects there is a linear relationship between the area of skin induration and the log-dose of the intradermal tuberculin injected in a constant volume. The area of skin induration is influenced by the volume of injected intradermal fluid as well as the tuberculin dose. A mathematical form is deduced to enable these variations to be predicted. A linear relationship is found to exist between the area of skin induration and the dose of infecting organisms. A study of the results occuring with BCG organisms in human subjects and Mycobacterium tuberculosis in guinea pigs is used to compare the sensitising ability of these organisms and calibrate the skin reaction in terms of the antigenic stimulus.
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