Abstract
The possible role of viruses in the etiology of malignant neoplasms has long been a subject for discussion and experimentation. Since a review of this literature is beyond the scope of this brief paper, it must suffice to mention previous pertinent reports. In 1936 Rous and Kidd found that intravenous injection of Shope rabbit papilloma virus activated tar warts on rabbits' ears to malignant degeneration. Andrewes, Ahlstrom, Foulds, and Gye in 1937 showed that rabbits injected intramuscularly with tar and then intravenously with the infectious fibroma virus (Shope) developed generalized fibromatosis, a phenomenon not observed in animals not treated with tar. Similar results were obtained when 3:4 benzpyrene was substituted for tar. Lacassagne and Nyka in a small series of animals observed that intravenous injection of Shope papilloma virus intensified the growth of cutaneous benzpyrene tumors (carcinoma) in rabbits. This effect was not obtained in rabbits in which the hypophysis was destroyed. In the following series of experiments the writers endeavored to determine whether injections of saline extracts from the common human wart, verruca vulgaris, might intensify the growth of and hasten malignant degeneration of benzpyrene warts on the ears of rabbits. Verruca vulgaris is classified as a virus disease and has been shown to be transmissible in man by injection of Berkefeld filtrates of the lesions.
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