Abstract
ABSTRACT Two cases of human microcephaly are described in which the hypothalamus and diencephalic regions of the brain, as well as parts of the medulla', were absent. The pituitaries were microscopically within normal limits, yet the adrenal cortices were markedly atrophic in that the fetal zone was almost totally absent. These findings are compatible with the theory that certain tissues of the central nervous system elaborate a principle that stimulates the pituitary to form hormone that maintains, or causes growth of, the fetal adrenal cortex. These findings also show that the secretory status of the pituitary is not always apparent from microscopic examination.
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