Abstract
Summary and Conclusions It has been confirmed that saponin has no effect on the results of the “overnight” frog method of assay for digitalis. The loss of potency during storage of digitalis tinctures is a real loss of cardiac activity in frogs, since it is shown by an intravenous method of assay. This method detects 20 to 30 per cent, loss of potency during 12 months storage as compared with up to 60 per cent, loss as shown by the lymph sac method of assay. A chemical assay based on the Keller-Kiliani colour reaction does not indicate loss of strength in digitalis tinctures during storage. Tinctures prepared from stabilised digitalis leaf are not stable on storage. 5 Digitoxin in ethanolic (70 per cent.) solution is stable on storage. 6 In aged tinctures of digitalis loss of potency to frogs appears to be due to hydrolysis of primary glycosides to secondary glycosides without further breakdown to genins.
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