Abstract

Experimental shock has been produced in the rat by clamping the hind legs. The mortality was related to the duration of limb ischaemia, as were the increased haemoglobin values. Adrenalectomized animals showed much greater susceptibility to trauma than did intact animals; DCA afforded no protection against trauma whereas adrenal cortical extract considerably improved the lowered tolerance. Conclusive evidence of development of resistance following repeated clamping was not obtained. Rats that had previously received a single clamping showed little evidence of resistance to drum trauma, whereas animals resistant to drumming showed increased tolerance when subjected to clamping.

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