Abstract

In over 90 per cent of healthy infants of normal birth weight, gamma-A globulin was first detected (>0.5 mg. per 100 ml.) in tears of infants between 10 and 20 days of age. Its appearance was slightly delayed in infants of low birth weight, but less markedly than was serum gamma-A globulin, so that in a proportion of low birth weight infants tear gamma-A globulin was detected first. No relationship was evident between conjunctival cultures from healthy infants and tear gamma-A globulin. Infective conjunctivitis in the first week of life caused significantly earlier appearance of tear gamma-A globulin. Gamma-A globulin was found in the tears of healthy infants throughout the neonatal period, with lowest concentrations in the second week of life when gamma-G globulin was undetectable (

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