Abstract
Six dogs were administered excessive quantities of ethanol daily through an esophagostomy, for periods ranging from 10 to 18 months. Ethanol levels of venous blood after alcohol was administered ranged from 315 to 477 mg%. Animals were fed a balanced diet. Serial biopsy specimens of the liver revealed fatty metamorphosis in 4 of 6 dogs, as well as degenerative changes of the hepatocytes, including eosinophilic hyaline bodies, cellular necrosis, infiltration with polymorphonuclear leukocytes and centrolobular fibrosis. These histologic alterations of the liver are comparable to those observed in patients with alcoholic hepatitis or alcoholic liver disease other than cirrhosis. In 3 control dogs, there were no changes in hepatic function or in the histologic appearance of the liver. Liver function abnormalities which developed included elevations of serum alkaline phosphatase, serum glutamic pyruvic transaminase and glutamic oxalacetic transaminase, and decreased serum albumin levels. The present investigation indicates that daily administration of excessive amounts of ethanol over a prolonged period can produce hepatic lesions similar to those observed in human alcoholic liver disease.
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