Observations on Day 3 Embryo Morphology and Chromosomal Status in the Older Patient

Abstract

Preimplantation genetic diagnosis (PGD) has been an invaluable tool in the study of increased aneuploidy rates with oocytes from older patients. The technique is however labor intensive , requires expertise and necessitates growth of the embryo in vitro to the blastocyst stage. Moreover, embryonic mosaicism may result in misdiagnosis and discarding of normal embryos. Thus, the use of preimplantation genetic diagnosis for aneuploidy has been recommended primarily for patients with a larger pool of embryos.