Abstract
ABSTRACT The effects of prolonged fasting on the metabolism of calcium, phosphorus, magnesium, nitrogen and hydroxyproline have been investigated in 4 obese adult subjects and in 1 obese patient with hypoparathyroidism. In all subjects, fasting produced acidosis and negative balances of calcium, phosphorus, magnesium and nitrogen and increases in urinary hydroxyproline. These changes were reversed with refeeding. Increases in urinary calcium, magnesium and hydroxyproline occurred in 1 subject even when acidosis was prevented by neutral phosphate buffer. The results indicate that fasting is accompanied by an alteration in the metabolism of collagen. This effect is not mediated by parathyroid glands, by acidosis or by phosphorus deprivation.
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