Observational study to evaluate pressor response to laryngoscopy and tracheal intubation after pre-operative nebulisation of lignocaine

Abstract

Background & Aims: - Direct laryngoscopy and intubation are essential steps in general anaesthesia which elicit significant adreno sympathetic responses. Suppression of these responses is a concern in general anaesthesia. The aim of our study is to evaluate haemodynamic effects of pre-operative nebulisation with lignocaine due to pressor response. Materials and Methods :- Fifty patients within the age group of 18-65 years undergoing elective surgery under general anaesthesia were randomly allocated into two groups: Group L (n=25) nebulised with 5 ml lignocaine (2%) and Group C (n=25) nebulised with 5 ml normal saline, 15 minutes before surgery. Baseline values of heart rate (HR), systolic blood pressure(SBP), diastolic blood pressure(DBP), mean arterial pressure(MAP) and saturation(SpO2) were noted. HR, SBP, DBP, MAP and SpO2 were noted immediately after intubation, at 2 minutes, 5 minutes and 10 minutes after intubation. Results:- There was significant fall in HR (88.76 ± 8.54) and MAP (93.32 ± 14.42) in group L as compared to group C. Conclusion:- This study suggests that pre-operative nebulisation with lignocaine significantly suppresses pressor response to laryngoscopy and intubation.