Observational study to compare histologically confirmed benign and malignant papillary neoplasm with demographic parameters and features of neoplasm

Abstract

Papillary lesions of the breast encompass a wide spectrum of benign and malignant entities. Cytological interpretation of these is difficult and they top the list of conditions with a risk of false-positive diagnosis. Understanding the correlation of histologically confirmed benign and malignant papillary neoplasm with demographic parameters and features of neoplasm will help to distinguish the different lesions. To compare histologically confirmed benign and malignant papillary neoplasm with demographic parameters and features of neoplasm A retrospective study was performed from January 2010 to December 2015 in the cytology section, Department of Pathology of a tertiary care and referral hospital including patients diagnosed as papillary lesion on FNAC. Histopathological follow-up was available for total 44 cases. A total of 44 breast aspirates and their corresponding histology were reviewed. Majority of the patients with benign and malignant neoplasm had age between 41-50 years (33%) and 51-60 years. All patients with benign neoplasm were women whereas among patients with malignant neoplasm 12 were women and one was a man. Benign papilloma, 36.3% cases showed cellular smear, followed by 27.2% showed moderate cellularity. Malignant papillary lesions, cases showed both cellular and moderate cellularity. Papillary carcinoma is an infrequent histologic subtype of breast carcinoma. Cytological diagnosis of the lesion is difficult due to overlap with benign entity and other mimics.