Observational study on TIVA with TCI propofol and TCI remifentanil for day case gynaecological laparoscopic surgery without muscle relaxants

Abstract

Infusion device performance The infusion devices were used to administer 1% propofol by TCI (at target blood propofol concentrations of 0.5 and 6.0 lg.ml for 120 min). Devices used were: (i) Alaris Asena PK pump; (ii) Graseby 3500 pump; (iii) a Fresenius Orchestra Base Primea TCI infusion system; (iv) a PC running Stanpump software controlling a Graseby 3500 pump. For each device the propofol syringe was connected to a 200 cm long intravenous infusion administration set, which was in turn connected to a 22G intravenous cannula. The cannula was attached to and its tip directed into, a measuring flask placed on a high precision scale. At 10-min intervals, for each system, the cumulative mass of propofol delivered was recorded and used to calculate the administered volume for each 10-min epoch (Volmeas). We also recorded from the user interface the cumulative volume that the system estimated it had delivered (Volest). For each epoch, j, 10-min error was defined as: (Volmeas,j ) Volest,j) ⁄Volest,j · 100. Experiments were conducted under identical conditions; the flask was sealed to avoid evaporation during the experiment. Results