Abstract
Functional constipation is relatively common in both adults and children, exhibiting similar symptoms. However, there are significant differences in the epidemiology, symptomatology, pathophysiology, diagnostic tests, and treatment management of functional constipation by age. The treatment of functional constipation is generally based on lifestyle interventions, pelvic floor interventions, and pharmacotherapy. Pharmacological treatment is popular as the most direct and effective modality, especially the herbal preparations (e.g., Shouhui Tongbian capsule), which are popular for their lower toxic side effects and less physiological reactions. In our clinical study, patients with functional constipation who took Shouhui Tongbian capsules for a longer period of time showed significantly better improvement than those who took them for a shorter period of time (P < 0.001). Relative to the duration of the disease, the improvement effect was higher in patients with short duration of the disease than in patients with long duration of the disease (P < 0.001). What's more, Shouhui Tongbian capsule had a regulating effect on intestinal flora, and the regulating effect was stronger in patients with a shorter disease duration.
Highlights
Chronic constipation is a common disease caused by many reasons
Due to the accelerating pace of modern life, increasing work pressure, and huge changes in eating habits, more and more people are prone to chronic constipation
Enteric neuropathy, smooth muscle degeneration, central neuropathy, and gastrointestinal hormone abnormalities are related to the etiology [22]
Summary
Constipation caused by abnormal function of the large intestine and anus is called functional constipation [1,2,3]. Constipation causes common anal diseases such as anal fissure and hemorrhoids, and causes the occurrence and development of cardiovascular and cerebrovascular diseases. In severe cases, it can cause colon cancer, which is life-threatening [8,9,10]
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