Observation on the efficacy of periocular triamcinolone acetonide injection in preventing delayed uveitis after cataract surgery in diabetic patients

Abstract

Objective To observe the efficacy of periocular triamcinolone acetonide(TA) injection for preventing delayed uveitis after phacoemulsification in diabetic patients. Methods The data of 592 eyes of 592 diabetic patients with cataract who received phacoemulsification combined with intraocular lens implantation from Jan. 2016 to Jun. 2018 were analyzes retrospectively. All patients were divided into three groups randomly. Group A, 197 eyes received phacoemulsification without medicine injection. Group B, 206 eyes received subconjunctival injection of dexamethasone (2.5 mg) after phacoemulsification, while 189 eyes in group C received periocular injection of TA (20 mg) after phacoemulsification. The follow-up time was for 1-3 months after surgery. Results Twelve eyes (6.1%) in group A suffered from delayed uveitis after surgery, 4 eyes (1.9%) in group B and 1 eye (0.5%) in group C. The difference of the incidence of delayed uveitis was not statistically significant between group A and B (χ2=4.55, P=0.03>0.0167), and the difference was statistically significant between group A and C(χ2=9.17, P=0.00 0.0167). Conclusion Periocular injection of TA and subconjunctival injection of dexamethasone are effective in controlling delayed uveitis in diabetic patients following phacoemulsification. Key words: Diabetes mellitus; Cataract; Phacoemulsification; Uveitis, delayed; Triamcinolone acetonide; Periocular injection