Observation on the effect of Pentazocine pre-emptive analgesia in patients receiving intercostal nerve cryoanalgesia after post-thoracotomy

Abstract

Objective To observe the effect ofpentazocine pre-emptive analgesia in patients receiving intercostal nerve cryoanalgesia after post-thoracotomy.Methods 60 patients with elective thoracotomy (ASA grade Ⅰ to grade Ⅱ ) were randomly divided into pre-emptive analgesia group (group A) and the control group (group B).Group A (n=30)received slow bolus injection of pentazocine 0.5 mg/kg 10 minutes before the beginning of operation.Patients in group B (n=30) were injected with saline (0.9％,2ml).Then we recorded the spontancous breathing recovery time,eyes open time and extubation time and analgesia.Visual analong scale scores (VAS) were used for pain degree score evaluation,and also 8CS at 1,4,8,24 hours after operation.We recorded the incidence of disadvantage between the two groups.Results There was no significant difference on the spontaneous breathing recovery time,eyes open time and extubation time between the two groups.VAS of group A was lower than that of group B (P＜0.05).BCS of group A was higher than thatof group B (P＜0.05).The incidence of disadvantage in group A was lower than that in group B (P＜0.05).Conclusion Preoperative application of pentazocine 0.5 mg/kg can effectively reduce the pain of post-thoracotomy patients receiving intercostal nerve cryoanalgesia and will not lead delayed recovery. Key words: Pentazocine; Pre-emptive analgesia; Thoracotomy; Intercostal nerve cryoanalgesi