Observation on the effect of Kuntai capsule combined with comples packing estradiol tablets/estradiol and dydrogesterone tablets in the treatment of perimenopausal syndrome and its influence on sex hormones, anti-Mullerian hormone and bone mineral density

Abstract

Objective To investigate the effect of Kuntai capsule combined with fenmotong in the treatment of perimenopausal syndrome and its effects on sex hormone, anti-Mullerian hormone (AMH) and bone mineral density (BMD). Methods One hundred and eighteen patients with perimenopausal syndrome admitted to Ningbo Development Zone Central Hospital from January 2018 to January 2019 were randomly divided into observation group (59 cases) and control group (59 cases). The patients in the control group were treated with Fenmotong, while the patients in the observation group were treated with Kuntai capsule on the basis of the control group. Both groups took 28 d as a cycle for 6 consecutive cycles. The changes of Kupperman menopausal index (KMI), sex hormone, AMH and bone mineral density before and after treatment were compared between the two groups. Results The KMI score of the observation group was lower than that of the control group [(6.27 ± 1.42) scores vs. (9.89 ± 1.74) scores](t=12.381, P<0.05). The level of serum estradiol (E2) in the observation group was higher than that in the control group [(195.48 ± 12.43) pmol/L vs. (165.65 ± 10.76) pmol/L], while the levels of serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the observation group were lower than those in the control group [(35.46 ± 1.76) U/L vs. (39.92 ± 2.13) U/L, (36.57 ± 2.34) U/L vs. (40.38 ± 1.89)U/L](P<0.05). The serum AMH level of the observation group was higher than that of the control group [(3.24 ± 0.68) μg/L vs. (1.97 ± 0.57) μg/L] (t=10.994, P<0.05). The BMD of the observation group was higher than that of the control group [(0.87 ± 0.13) g/cm2 vs. (0.71 ± 0.07) g/cm2](t=8.324, P<0.05). Conclusions Kuntai capsule combined with Fenmotong has a good effect in the treatment of perimenopausal syndrome. It can improve the level of sex hormones, AMH and bone mineral density. Key words: Perimenopausal syndrome; Sex hormone; Anti-mullerian hormone; Bone mineral density; Kuntai capsule; Comples packing estradiol tablets/estradiol and dydrogesterone tablets