Abstract
Objective To investigate the specific effects and safety of combined immunization of live attenuated epidemic encephalitis B vaccine and live attenuated vaccine against varicella. Methods A total of 153 vaccinated children were grouped according to the types of vaccination, including the encephalitis B vaccine group (n=51), varicella vaccine group (n=51) and combination group (n=51). Subcutaneous injection of live attenuated epidemic encephalitis B vaccine was given to the encephalitis B vaccine group. Subcutaneous injection of live attenuated varicella vaccine was given to the varicella vaccine group. Combination group was given subcutaneous injection of live attenuated epidemic encephalitis B vaccine combined with the live attenuated varicella vaccine in left and right arms. The antibody seroconversion rate and antibody titer before and after inoculation were compared between encephalitis B vaccine group and combination group, and between varicella vaccine group and combination group; the incidences of adverse reactions among three groups were counted and compared. Results There was no significant difference in the antibody positive rate between encephalitis B vaccine group (68.63%) and combination group(64.71%) before inoculation (P>0.05); after inoculation, the positive rate of antibody in the two groups were higher than those before inoculation (P 0.05; after inoculation, the antibody titer of encephalitis B vaccine in the two groups was higher than that before inoculation (P 0.05). Before inoculation, there was no significant difference in the positive rate of antibody between varicella vaccine group (64.71%) and combination group (60.78%), P>0.05; after inoculation, the positive rate of antibody in the two groups was higher than that before inoculation (P 0.05; after inoculation, the titer of varicella antibody in the two groups was higher than that before inoculation (P 0.05). There was no significant difference in the incidence of adverse reactions among the encephalitis B vaccine group(5.88%), varicella vaccine group (11.76%) and combination group (7.84%), P>0.05. Conclusions The specific effect of live attenuated epidemic encephalitis B vaccine combined with live attenuated varicella vaccine is similar to that of single vaccines, and it has high safety. It is beneficial to reduce the frequency of vaccination, and has positive significance to reduce the incidence of late and missed vaccination. Key words: Live attenuated epidemic encephalitis B vaccine; Live attenuated varicella vaccine; Safety
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