Observation on the curative effect of roxadustat in treatment of refractory renal anemia in patients with maintenance hemodialysis

Abstract

Objective To observe the efficacy and safety of roxadustat in treatment of refractory renal anemia in patients with maintenance hemodialysis. Methods Sixty-five renal anemia patients with unsatisfactory results of recombinant human erythropoietin (rhEPO) combined with iron who undergoing maintenance hemodialysis were selected as research objects. They were randomly divided into experimental group (n=33) and control group (n=32). The experimental group was treated with oral roxadustat capsule, while the control group was treated with rhEPO, and the two groups were treated with oral iron for 6 weeks. Anemia indexes[hematocrit (Hct), hemoglobin (Hb)] and iron metabolism indexes[transferrin (TRF), transferrin saturation (TSAT), total iron binding capacity (TIBC)] were compared between the two groups before and after treatment, and adverse events in the two groups were recorded. Results After 6 weeks of treatment, the levels of Hb, Hct, TIBC and TRF in the experimental group were significantly higher than those in the control group (P 0.05). The incidence of adverse events in experimental group was significantly lower than that in control group (P Conclusion The efficacy of roxadustat capsule in treatment of refractory renal anemia in patients with maintenance hemodialysis is better than rhEPO, and it has fewer adverse reactions. It is convenient for oral administration, and a safe and effective therapy.